gamma-interferon (Meaning)

Wordnet

gamma-interferon (n)

a form of interferon that is produced by T cells and macrophages; involved in the activation of phagocytes

No Synonyms and anytonyms found

Gamma-interferon (IFN-γ) plays a crucial role in the cellular immune response against viral and bacterial infections.
IFN-γ is produced by activated T cells and natural killer cells in response to specific antigens.
It enhances the expression of MHC class I and II molecules on target cells, making them more recognizable to cytotoxic T cells.
IFN-γ promotes macrophage activation and polarization towards a pro-inflammatory M1 phenotype.
Its antiviral effects are mediated by the induction of STAT1 phosphorylation and the upregulation of antiviral proteins.
IFN-γ also exhibits antitumor activity by inhibiting cell proliferation, inducing apoptosis, and promoting immune surveillance.
Dysregulation of IFN-γ production is associated with various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.
Recombinant IFN-γ is used therapeutically to treat certain chronic granulomatous diseases and severe viral infections.
The gamma-interferon release assay (IGRA) is a diagnostic tool for detecting latent tuberculosis infection.
Continued research on IFN-γ's molecular mechanisms and clinical applications is essential for advancing our understanding of immune-mediated diseases and developing novel therapies.

a form of interferon that is produced by T cells and macrophages; involved in the activation of phagocytes

No synonyms found.

No antonyms found.

Gamma-interferon (IFN-γ) plays a crucial role in the cellular immune response against viral and bacterial infections.

IFN-γ is produced by activated T cells and natural killer cells in response to specific antigens.

It enhances the expression of MHC class I and II molecules on target cells, making them more recognizable to cytotoxic T cells.

IFN-γ promotes macrophage activation and polarization towards a pro-inflammatory M1 phenotype.