plasma thromboplastin antecedent Synonyms
No Synonyms and anytonyms found
plasma thromboplastin antecedent Meaning
Wordnet
plasma thromboplastin antecedent (n)
coagulation factor whose deficiency results in a hemorrhagic tendency
plasma thromboplastin antecedent Sentence Examples
- Plasma thromboplastin antecedent (PTA), also known as factor XI, is an essential protein in the coagulation cascade.
- PTA deficiency, a rare bleeding disorder, results from mutations in the PTA gene and impaired PTA protein function.
- PTA binds to factor IX in the presence of calcium and phospholipids, forming a complex called the intrinsic tenase complex.
- The intrinsic tenase complex activates factor X, which in turn converts prothrombin to thrombin, leading to clot formation.
- Plasma thromboplastin antecedent antibodies can inhibit PTA activity, causing an inherited bleeding disorder known as PTA inhibitor.
- PTA is synthesized in the liver and is present in circulation as a zymogen, which requires activation to become fully functional.
- The activation of PTA is a complex process involving several other coagulation factors, including factor XII, prekallikrein, and high-molecular-weight kininogen.
- The deficiency of plasma thromboplastin antecedent can lead to an impaired coagulation cascade and an increased risk of bleeding.
- Measuring plasma thromboplastin antecedent levels can help in diagnosing bleeding disorders and monitoring the efficacy of treatment.
- Novel therapies, such as gene therapy, are being explored to address plasma thromboplastin antecedent deficiency and improve hemostasis in affected individuals.
FAQs About the word plasma thromboplastin antecedent
coagulation factor whose deficiency results in a hemorrhagic tendency
No synonyms found.
No antonyms found.
Plasma thromboplastin antecedent (PTA), also known as factor XI, is an essential protein in the coagulation cascade.
PTA deficiency, a rare bleeding disorder, results from mutations in the PTA gene and impaired PTA protein function.
PTA binds to factor IX in the presence of calcium and phospholipids, forming a complex called the intrinsic tenase complex.
The intrinsic tenase complex activates factor X, which in turn converts prothrombin to thrombin, leading to clot formation.
