urokinase (Meaning)
Wordnet
urokinase (n)
protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
Synonyms & Antonyms of urokinase
No Synonyms and anytonyms found
urokinase Sentence Examples
- Urokinase is a serine protease that plays a crucial role in the regulation of fibrinolysis, the process of breaking down blood clots.
- Elevated levels of urokinase have been associated with increased risk of bleeding and thromboembolic events.
- Urokinase is produced by various cell types, including endothelial cells, macrophages, and neutrophils.
- Tissue plasminogen activator (tPA) is the primary activator of urokinase, converting it from its inactive proform to its active form.
- Urokinase activates plasminogen to plasmin, which in turn degrades fibrin, the main protein component of blood clots.
- Urokinase has thrombolytic properties and is used as a therapeutic agent to dissolve blood clots in conditions such as deep vein thrombosis and pulmonary embolism.
- Urokinase therapy is typically administered through intravenous infusion or injection.
- The use of urokinase is associated with a risk of bleeding complications, so it is generally reserved for severe cases of blood clot formation.
- Research is ongoing to develop more specific and safer urokinase-based therapies for the treatment of thrombotic disorders.
- Urokinase activity is regulated by various factors, including inhibitors such as plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator receptor (uPAR).
FAQs About the word urokinase
protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
No synonyms found.
No antonyms found.
Urokinase is a serine protease that plays a crucial role in the regulation of fibrinolysis, the process of breaking down blood clots.
Elevated levels of urokinase have been associated with increased risk of bleeding and thromboembolic events.
Urokinase is produced by various cell types, including endothelial cells, macrophages, and neutrophils.
Tissue plasminogen activator (tPA) is the primary activator of urokinase, converting it from its inactive proform to its active form.
