secretase (Meaning)
secretase (n)
a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)
Synonyms & Antonyms of secretase
No Synonyms and anytonyms found
secretase Sentence Examples
- Gamma-secretase is an enzyme complex that plays a crucial role in the processing of amyloid precursor protein.
- Beta-secretase is another enzyme that initiates the amyloidogenic pathway by cleaving amyloid precursor protein.
- Presenilin deletions can lead to familial Alzheimer's disease by altering gamma-secretase activity.
- BACE1 is the primary beta-secretase enzyme involved in Alzheimer's disease.
- Secretase inhibitors are potential therapeutic agents for Alzheimer's disease by targeting amyloid precursor protein processing.
- The secretase cascade generates amyloid-beta peptides that form toxic aggregates in Alzheimer's disease.
- Alpha-secretase cleaves amyloid precursor protein to produce non-amyloidogenic products.
- Dysregulated secretase activity is associated with several neurodegenerative disorders.
- Secretase modulators are being investigated for their potential in treating various diseases, including Alzheimer's and cancer.
- The exact mechanisms by which secretases contribute to disease remain under investigation.
FAQs About the word secretase
a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain t
No synonyms found.
No antonyms found.
Gamma-secretase is an enzyme complex that plays a crucial role in the processing of amyloid precursor protein.
Beta-secretase is another enzyme that initiates the amyloidogenic pathway by cleaving amyloid precursor protein.
Presenilin deletions can lead to familial Alzheimer's disease by altering gamma-secretase activity.
BACE1 is the primary beta-secretase enzyme involved in Alzheimer's disease.
