cyclooxygenase-1 (Meaning)
Wordnet
cyclooxygenase-1 (n)
an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys
Synonyms & Antonyms of cyclooxygenase-1
No Synonyms and anytonyms found
cyclooxygenase-1 Sentence Examples
- Cyclooxygenase-1 (COX-1) is a constitutively expressed enzyme involved in the synthesis of prostaglandins.
- Unlike cyclooxygenase-2 (COX-2), COX-1 is primarily responsible for maintaining physiological functions such as gastric mucosal integrity.
- COX-1 is expressed in various tissues including the stomach, kidneys, and platelets.
- Inhibition of COX-1 can lead to adverse effects such as gastric ulcers and bleeding disorders.
- Some nonsteroidal anti-inflammatory drugs (NSAIDs) target both COX-1 and COX-2, increasing the risk of gastrointestinal complications.
- COX-1-derived prostaglandins regulate blood flow to the kidneys and protect the gastric mucosa from damage.
- Dysregulation of COX-1 activity has been implicated in the pathogenesis of aspirin-exacerbated respiratory disease (AERD).
- COX-1 inhibition by aspirin leads to decreased synthesis of prostaglandin E2 and thromboxane A2, contributing to its anti-inflammatory and antiplatelet effects.
- COX-1 is considered a promising target for the development of drugs aimed at reducing inflammation without gastrointestinal side effects.
- Research continues to elucidate the distinct roles of COX-1 and COX-2 in health and disease, providing insights for the design of more selective therapeutics.
FAQs About the word cyclooxygenase-1
an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys
No synonyms found.
No antonyms found.
Cyclooxygenase-1 (COX-1) is a constitutively expressed enzyme involved in the synthesis of prostaglandins.
Unlike cyclooxygenase-2 (COX-2), COX-1 is primarily responsible for maintaining physiological functions such as gastric mucosal integrity.
COX-1 is expressed in various tissues including the stomach, kidneys, and platelets.
Inhibition of COX-1 can lead to adverse effects such as gastric ulcers and bleeding disorders.
