hageman factor Synonyms
No Synonyms and anytonyms found
hageman factor Meaning
Wordnet
hageman factor (n)
coagulation factor whose deficiency results in prolongation of clotting time of venous blood
hageman factor Sentence Examples
- Hageman factor, a coagulation protein precursor, plays a critical role in initiating the intrinsic pathway of blood coagulation.
- Inherited deficiencies of hageman factor are rare, but can lead to a predisposition to bleeding disorders.
- Hageman factor is activated by various surfaces, including glass, silica, and activated platelets.
- Upon activation, hageman factor undergoes conformational changes, exposing a catalytic site.
- Hageman factor then initiates the coagulation cascade by activating factor XI and prekallikrein.
- Factor XIa, generated by hageman factor, further activates factor IX, linking the intrinsic and extrinsic pathways.
- Hageman factor also plays a role in the activation of the complement system, enhancing its pro-inflammatory effects.
- Studies have suggested that hageman factor may be involved in the development of certain inflammatory diseases.
- Mutations in the hageman factor gene have been associated with an increased risk of venous thromboembolism.
- Targeting hageman factor could provide a novel therapeutic strategy for treating coagulation disorders and inflammatory diseases.
FAQs About the word hageman factor
coagulation factor whose deficiency results in prolongation of clotting time of venous blood
No synonyms found.
No antonyms found.
Hageman factor, a coagulation protein precursor, plays a critical role in initiating the intrinsic pathway of blood coagulation.
Inherited deficiencies of hageman factor are rare, but can lead to a predisposition to bleeding disorders.
Hageman factor is activated by various surfaces, including glass, silica, and activated platelets.
Upon activation, hageman factor undergoes conformational changes, exposing a catalytic site.
